Name: Parkinson's Disease
Cause: The gene that causes people to inherit Parkinson's Disease, coded for a protein called alpha-synuclein. If you study the brains of people with Parkinson’s Disease after they die, you can see tiny little accumulations of protein called Lewy Bodies (which were named after the doctor who first found them). Research has shown that there is a large amount of alpha-synuclein protein in the Lewy Bodies of people who have non-inherited PD and in the brains of people who have inherited PD. This immediately told us that alpha-synuclein played an important role in all forms of PD.
http://www.genome.gov/10001217#3
http://www.genome.gov/10001217#3
Symptoms:
☁ Movements become slowed, especially when you’re walking or rolling over in bed.
☉ Decreased facial expression, monotonous speech, and decreased eye blinking.
∬ A shuffling walk with barely any arm swing and stooped posture.
✖ Unsteady balance; difficulty rising from a sitting position.
≌ Continuous "pill-rolling" motion of the thumb and forefinger.
❖ Abnormal tone or stiffness in the trunk and extremities.
☔ Swallowing problems in later stages.
http://www.webmd.com/parkinsons-disease/guide/parkinsons-overview-facts
☁ Movements become slowed, especially when you’re walking or rolling over in bed.
☉ Decreased facial expression, monotonous speech, and decreased eye blinking.
∬ A shuffling walk with barely any arm swing and stooped posture.
✖ Unsteady balance; difficulty rising from a sitting position.
≌ Continuous "pill-rolling" motion of the thumb and forefinger.
❖ Abnormal tone or stiffness in the trunk and extremities.
☔ Swallowing problems in later stages.
http://www.webmd.com/parkinsons-disease/guide/parkinsons-overview-facts
Inheritance: If the LRRK2 or SNCA gene is involved, Parkinson’s is inherited in a pattern where one copy of an altered gene in each cell, is the one to cause the disorder. In most cases, an affected person has one parent with the condition.
If the PARK2, PARK7, or PINK1 gene is involved, Parkinson disease is a recessive gene, so you will not necessarily get this disease if one of your parents have it. Usually, the parents of a person with this recessive gene of Parkinson’s disease, each carry one copy of the altered gene but do not show signs and symptoms of the disorder.
http://ghr.nlm.nih.gov/condition/parkinson-disease#inheritance
If the PARK2, PARK7, or PINK1 gene is involved, Parkinson disease is a recessive gene, so you will not necessarily get this disease if one of your parents have it. Usually, the parents of a person with this recessive gene of Parkinson’s disease, each carry one copy of the altered gene but do not show signs and symptoms of the disorder.
http://ghr.nlm.nih.gov/condition/parkinson-disease#inheritance
Incidence: About 1 million people, both men and women, in the United States have Parkinson's disease. Symptoms usually appear when someone is older than 50, and it also becomes more common as people get older. Although the role that heredity plays isn't completely understood, we do know that if a close relative like a parent, brother, or sister has Parkinson's, there is a greater chance of developing the disease. But Parkinson's disease is not guaranteed if someone you are related to has it, because it is a recessive gene.
http://kidshealth.org/kid/grownup/conditions/parkinson.html
http://kidshealth.org/kid/grownup/conditions/parkinson.html
Treatment: At this current time there is no treatment offered. However, there is medication to control the symptoms.
http://kidshealth.org/kid/grownup/conditions/parkinson.html
http://kidshealth.org/kid/grownup/conditions/parkinson.html
Other: If the person with this disorder gets left untreated, the disorder will get worse until a person is totally disabled. Parkinson's may also lead to a deterioration of all brain functions, and an early death.
http://www.webmd.com/parkinsons-disease/guide/parkinsons-overview-facts
http://www.webmd.com/parkinsons-disease/guide/parkinsons-overview-facts